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Interacting motif networks located in hotspots associated with RNA release are conserved in Enterovirus capsids
Author(s) -
Ross Caroline,
Knox Caroline,
Tastan Bishop Özlem
Publication year - 2017
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12663
Subject(s) - capsid , enterovirus 71 , rna , structural motif , enterovirus , motif (music) , chemistry , microbiology and biotechnology , virology , computational biology , biology , genetics , virus , biochemistry , gene , physics , acoustics
Enteroviruses are responsible for a multitude of human diseases. Expansion of the virus capsid is associated with a cascade of conformational changes that allow the subsequent release of RNA . For the first time, this study presents a comprehensive bioinformatic screen for the prediction of interacting motifs within intraprotomer interfaces and across respective interfaces surrounding the fivefold and twofold axes. The results identify a network of conserved motif residues involved in interactions in enteroviruses that may be critical to capsid stabilisation, providing guidelines towards developing antivirals that interfere with viral expansion during RNA release.