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Generation of wavy structure on lipid membrane by peripheral proteins: a linear elastic analysis
Author(s) -
Mahata Paritosh,
Das Sovan Lal
Publication year - 2017
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12661
Subject(s) - peripheral membrane protein , biophysics , chemistry , membrane protein , lipid bilayer , membrane , peripheral , materials science , biochemistry , integral membrane protein , biology , medicine
We carry out a linear elastic analysis to study wavy structure generation on lipid membrane by peripheral membrane proteins. We model the lipid membrane as linearly elastic and anisotropic material. The hydrophobic insertion by proteins into the lipid membrane has been idealized as penetration of rigid rod‐like inclusions into the membrane and the electrostatic interaction between protein and membrane has been modeled by a distributed surface traction acting on the membrane surface. With the proposed model we study curvature generation by several binding domains of peripheral membrane proteins containing BAR domains and amphipathic alpha‐helices. It is observed that electrostatic interaction is essential for curvature generation by the BAR domains.