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A farnesoic acid‐responsive transcription factor, Hot1, regulates yeast‐hypha morphogenesis in Candida albicans
Author(s) -
Ahn ChanHong,
Lee Sohyoung,
Cho Eunji,
Kim Heegyu,
Chung Beomkoo,
Park Wanki,
Shin Jongheon,
Oh KiBong
Publication year - 2017
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12636
Subject(s) - candida albicans , yeast , morphogenesis , hypha , transcription factor , microbiology and biotechnology , chemistry , corpus albicans , fungal protein , biology , biochemistry , saccharomyces cerevisiae , gene
Candida albicans hyphal formation is inhibited by a quorum‐sensing molecule, farnesoic acid, which accumulates in the medium as the cells proliferate. We recently showed that Pho81 is essential for the inhibition of hyphal growth by farnesoic acid. Here, we describe a newly identified regulator, Hot1, which increases the expression of PHO 81 . The binding site of Hot1 in the PHO 81 promoter region was identified by DN ase I protection assay. The hot1 Δ mutant grows extensively as filaments. Furthermore, the inhibition of hyphal formation and the repression of major signaling pathway components in response to farnesoic acid are defective in hot1 Δ mutant cells. These data suggest an important role for HOT 1 in the inhibition of hyphal development by farnesoic acid in this fungus.