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Smurf1 controls S phase progression and tumorigenesis through Wee1 degradation
Author(s) -
Wei Rongfei,
Guo Jing,
Li Mengyuan,
Yang Xingjiu,
Zhu Ruimin,
Huang Hao,
Li Kejuan,
Zhang Lingqiang,
Gao Ran
Publication year - 2017
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12624
Subject(s) - wee1 , ubiquitin ligase , smad , ubiquitin , cancer research , signal transduction , gene silencing , microbiology and biotechnology , chemistry , cell cycle , transforming growth factor , tumor progression , bone morphogenetic protein , transforming growth factor beta , biology , apoptosis , cancer , genetics , biochemistry , cyclin dependent kinase 1 , gene
Smad ubiquitination regulatory factor 1 (Smurf1) is a HECT ‐type E3 ubiquitin ligase that regulates several important signaling pathways, including the bone morphogenetic protein pathway and the transforming growth factor‐beta ( TGF ‐β) signaling pathway. However, the function of Smurf1 in cell cycle progression remains unclear. Here, we demonstrate that silencing of Smurf1 results in S phase arrest, confirming that Smurf1 is required for S phase progression. Furthermore, we demonstrate that Smurf1‐mediated S phase progression is largely dependent on the ubiquitination‐dependent degradation of Wee1. This study defines a novel role for Smurf1 in controlling S phase progression by promoting Wee1 degradation.