NLRP 6 facilitates the interaction between TAB 2/3 and TRIM 38 in rheumatoid arthritis fibroblast‐like synoviocytes

In the present study, we investigated the role of nucleotide oligomerization domain‐like receptor family pyrin domain containing 6 ( NLRP 6) in rheumatoid arthritis ( RA ) and explored the underlying mechanism. We found that both mRNA and protein levels of NLRP 6 are attenuated in synovial tissues and fibroblast‐like synoviocytes ( FLS ) of RA patients compared to patients with osteoarthritis. We also observed that pro‐inflammatory cytokine production is decreased and nuclear factor‐kappa B activation is inhibited in NLRP 6‐overexpressing RA ‐ FLS . Furthermore, we found that NLRP 6 overexpression promotes transforming growth factor‐b‐activated kinase 1‐binding protein 2/3 lysosome‐dependent degradation, and we provide evidence showing that NLRP 6 plays the role of providing the docking site to facilitate the interaction between transforming growth factor‐b‐activated kinase 1‐binding protein 2/3 and tripartite motif 38 in RA ‐ FLS .