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The competing endogenous RNA network of CYP 4Z1 and pseudogene CYP 4Z2P exerts an anti‐apoptotic function in breast cancer
Author(s) -
Li Cheng,
Zheng Lufeng,
Xin Yu,
Tan Zhoulin,
Zhang Yan,
Meng Xia,
Wang Zhigang,
Xi Tao
Publication year - 2017
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12608
Subject(s) - telomerase reverse transcriptase , pseudogene , cancer research , carcinogenesis , biology , telomerase , apoptosis , downregulation and upregulation , competing endogenous rna , microbiology and biotechnology , chemistry , cancer , genetics , gene , long non coding rna , genome
The competing endogenous RNA network (ce RNET ) is involved in tumorigenesis and has become a hot spot of research. The ce RNET between CYP 4Z1 and the pseudogene CYP 4Z2P promotes angiogenesis and mediates tamoxifen resistance in breast cancer. Nevertheless, the effects of this ce RNET on cell apoptosis and related mechanisms remain unclear. In the present study, we found that downregulation of CYP 4Z1 or the CYP 4Z2P 3′‐ UTR promotes cell apoptosis, mirroring the functions of human telomerase reverse transcriptase ( hTERT ). Furthermore, the ce RNET between CYP 4Z1 and pseudogene CYP 4Z2P modulates hTERT expression by operating as a sub‐ce RNET for hTERT . Our data demonstrate that the ce RNET between CYP 4Z1 and pseudogene CYP 4Z2P acts as a sub‐ce RNET for hTERT and, thus, inhibits breast cancer apoptosis.