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An invertebrate STING from shrimp activates an innate immune defense against bacterial infection
Author(s) -
Li Haoyang,
Wang Sheng,
Lǚ Kai,
Yin Bin,
Xiao Bang,
Li Sedong,
He Jianguo,
Li Chaozheng
Publication year - 2017
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12607
Subject(s) - innate immune system , shrimp , sting , microbiology and biotechnology , invertebrate , marine invertebrates , biology , immune system , chemistry , fishery , immunology , engineering , aerospace engineering
It has been proposed that invertebrate stimulators of interferon genes ( STING s) do not take part in the innate immune response to infection. Herein, we identified a new STING homolog from pacific white shrimp Litopenaeus vannamei (Lv STING ). Some amino acids crucial for recognizing cyclic dinucleotides in mammals are highly conserved in Lv STING . Moreover, Lv STING expression can be robustly induced by challenge with the Gram‐negative bacteria Vibrio parahaemolyticus . Silencing of Lv STING contributes to decreased expression of the antimicrobial peptide PEN 4 and renders shrimp more susceptible to V. parahaemolyticus infection, while coinjection with the recombinant Lv STING protein can rescue PEN 4 expression in vivo and confer shrimp with more resistance to infection. Taken together, these results suggest that Lv STING is involved in the innate immune response to bacterial infection.