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MLF 1 IP promotes normal erythroid proliferation and is involved in the pathogenesis of polycythemia vera
Author(s) -
Feng Gege,
Zhang Tianjiao,
Liu Jinqin,
Ma Xiaotang,
Li Bing,
Yang Lin,
Zhang Yue,
Xu Zefeng,
Qin Tiejun,
Zhou Jiaxi,
Huang Gang,
Shi Lihong,
Xiao Zhijian
Publication year - 2017
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12587
Subject(s) - erythropoiesis , pathogenesis , biology , genetically modified mouse , transgene , polycythemia vera , microbiology and biotechnology , myeloid , immunology , gene , genetics , medicine , anemia
Myelodysplasia/myeloid leukemia factor 1‐interacting protein ( MLF 1 IP ) appears to be an erythroid lineage‐specific gene in mice; however, its role in normal erythropoiesis and erythropoietic disorders have not yet been elucidated. Here, we found that MLF 1 IP is abundantly expressed in human erythroid progenitor cells and that MLF 1 IP ‐deficiency reduces cell proliferation resulting from cell cycle arrest. Moreover, MLF 1 IP expression is exclusively elevated in CFU ‐E cells from polycythemia vera ( PV ) patients, and MLF 1 IP transgenic mice develop a PV ‐like disorder. Further analyses revealed that the erythroid progenitors and early‐stage erythroblasts from these transgenic mice expand by up‐regulating cyclin D2 and down‐regulating p27 and p21. Thus, our data demonstrate that MLF 1 IP promotes erythroid proliferation and is involved in the pathogenesis of PV , suggesting that it might be a novel molecular target for erythropoietic disorders.