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Inhibition of platelet‐derived growth factor signaling prevents muscle fiber growth during skeletal muscle hypertrophy
Author(s) -
Sugg Kristoffer B.,
Korn Michael A.,
Sarver Dylan C.,
Markworth James F.,
Mendias Christopher L.
Publication year - 2017
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12571
Subject(s) - muscle hypertrophy , platelet derived growth factor receptor , platelet derived growth factor , skeletal muscle , medicine , endocrinology , growth factor , angiogenesis , microbiology and biotechnology , signal transduction , myocyte , biology , extracellular matrix , chemistry , receptor
The platelet‐derived growth factor receptors alpha and beta ( PDGFR α and PDGFR β) mark fibroadipogenic progenitor cells/fibroblasts and pericytes in skeletal muscle, respectively. While the role that these cells play in muscle growth and development has been evaluated, it was not known whether the PDGF receptors activate signaling pathways that control transcriptional and functional changes during skeletal muscle hypertrophy. To evaluate this, we inhibited PDGFR signaling in mice subjected to a synergist ablation muscle growth procedure, and performed analyses 3 and 10 days after induction of hypertrophy. The results from this study indicate that PDGF signaling is required for fiber hypertrophy, extracellular matrix production, and angiogenesis that occur during muscle growth.