Premium
Suppression of EIF 4G2 by miR‐379 potentiates the cisplatin chemosensitivity in nonsmall cell lung cancer cells
Author(s) -
Hao Guangjun,
Hao Haijun,
Ding Yanhui,
Wen Hui,
Li Xiaofeng,
Wang Qianru,
Zhang Bingbing
Publication year - 2017
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12566
Subject(s) - cisplatin , cancer research , chemistry , biology , medicine , chemotherapy
Although micro RNA s and EIF 4G2 are both known to play pivotal roles in cancer progression, it remains unknown whether these pathways regulate chemosensitivity in a coordinated manner. Here, we show that miR‐379 expression is significantly downregulated in chemoresistant nonsmall cell lung cancer ( NSCLC ) tissues and cells. Manipulation of miR‐379 levels could alter the in vitro and in vivo cisplatin ( CDDP ) resistance in lung cancer ( LC a) cells. Mechanistically, miR‐379 potentiated LC a chemosensitivity via modulation of CDDP ‐induced apoptosis by directly targeting the EIF 4G2 3′ UTR . Additionally, we observed an inverse correlation between miR‐379 and EIF 4G2 expression in LC a tissues from patients with CDDP ‐based chemotherapy. Together, our findings shed new light on the potential involvement of miR‐379/ EIF 4G2 cascade in the pathogenesis of CDDP resistance in LC a.