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Micro RNA ‐22 regulates inflammation and angiogenesis via targeting VE ‐cadherin
Author(s) -
Gu Wei,
Zhan Huihui,
Zhou XinYing,
Yao Lun,
Yan Meiping,
Chen Ao,
Liu Jie,
Ren Xiaojiao,
Zhang Xinhua,
Liu JingXia,
Liu Guoquan
Publication year - 2017
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12565
Subject(s) - inflammation , angiogenesis , microbiology and biotechnology , cadherin , ve cadherin , rna , chemistry , biology , cancer research , biochemistry , immunology , cell , gene
The vascular endothelial ( VE )‐cadherin functions as an endothelial barrier protein controlling endothelial permeability and leukocyte transmigration. Developmental studies indicate that VE ‐cadherin also plays a vital role in angiogenesis. Micro RNA ‐22 plays important roles in cardiovascular diseases including cardiac hypertrophy and heart failure. We identified that miR‐22 interacts with VE ‐cadherin mRNA . Overexpression of miR‐22 in endothelial cells increases the synthesis of proinflammatory cytokines. Injection of miR‐22 results in increased myeloperoxidase activity in the mouse lungs. Moreover, miR‐22 injection into the fluorescent‐labeled transgenic zebrafish Tg(fli1: EGFP ) embryos caused defective vascular development in the dorsal and intersegmental vessels, and vascular markers were significantly suppressed in these embryos. Our studies demonstrate that the conserved targeting of VE ‐cadherin by miR‐22 regulates endothelial inflammation, tissue injury, and angiogenesis.