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Moonlighting at replication forks – a new life for homologous recombination proteins BRCA 1, BRCA 2 and RAD 51
Author(s) -
Kolinjivadi Arun Mouli,
Sannino Vincenzo,
Antoni Anna,
Técher Hervé,
Baldi Giorgio,
Costanzo Vincenzo
Publication year - 2017
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12556
Subject(s) - rad51 , homologous recombination , replication protein a , nuclease , microbiology and biotechnology , dna repair , dna replication , dna , biology , genetics , dna binding protein , gene , transcription factor
Coordination between DNA replication and DNA repair ensures maintenance of genome integrity, which is lost in cancer cells. Emerging evidence has linked homologous recombination ( HR ) proteins RAD 51, BRCA 1 and BRCA 2 to the stability of nascent DNA . This function appears to be distinct from double‐strand break ( DSB ) repair and is in part due to the prevention of MRE 11‐mediated degradation of nascent DNA at stalled forks. The role of RAD 51 in fork protection resembles the activity described for its prokaryotic orthologue RecA, which prevents nuclease‐mediated degradation of DNA and promotes replication fork restart in cells challenged by DNA ‐damaging agents. Here, we examine the mechanistic aspects of HR ‐mediated fork protection, addressing the crosstalk between HR and replication proteins.