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Conversion of an instantaneous activating K + channel into a slow activating inward rectifier
Author(s) -
Baumeister Dirk,
Hertel Brigitte,
Schroeder Indra,
Gazzarrini Sabrina,
Kast Stefan M.,
Van Etten James L.,
Moroni Anna,
Thiel Gerhard
Publication year - 2017
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12536
Subject(s) - inward rectifier potassium ion channel , gating , rectification , chemistry , voltage , biophysics , rectifier (neural networks) , ion channel , channel (broadcasting) , potassium channel , electrical engineering , biochemistry , computer science , engineering , biology , receptor , stochastic neural network , machine learning , recurrent neural network , artificial neural network
The miniature channel, Kcv, is a structural equivalent of the pore of all K + channels. Here, we follow up on a previous observation that a largely voltage‐insensitive channel can be converted into a slow activating inward rectifier after extending the outer transmembrane domain by one Ala. This gain of rectification can be rationalized by dynamic salt bridges at the cytosolic entrance to the channel; opening is favored by voltage‐sensitive formation of salt bridges and counteracted by their disruption. Such latent voltage sensitivity in the pore could be relevant for the understanding of voltage gating in complex Kv channels.