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miR‐429 is involved in regulation of NF ‐κBactivity by targeting IKK β and suppresses oncogenic activity in cervical cancer cells
Author(s) -
Fan Jingyi,
Fan Yajie,
Wang Xiangling,
Xie Hong,
Gao Huijie,
Zhang Yi,
Liu Min,
Tang Hua
Publication year - 2017
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12502
Subject(s) - nf κb , chemistry , cancer research , microbiology and biotechnology , cancer , cancer cell , biology , signal transduction , medicine
Dysregulation of micro RNA s (mi RNA s) can contribute to tumorigenesis in cancers. In this study, we found that miR‐429 was downregulated in cervical cancer (CC) tissues and suppressed cell viability and proliferation while promoting apoptosis in CC cells. IKK β was a novel target gene of miR‐429 and ectopic expression of IKK β abrogated the phenotypes induced by miR‐429. When IKK β was downregulated by miR‐429, nuclear factor κB ( NF ‐κB) pathway activation, interleukin‐6 ( IL ‐6), and interferon‐β ( IFN ‐β) production were decreased in CC cells. These findings indicate that miR‐429 is involved in regulation of the NF ‐κB pathway by targeting IKK β and functions as a tumor suppressor in cervical carcinogenesis.