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KCNMA 1, a pore‐forming α‐subunit of BK channels, regulates insulin signalling in mature adipocytes
Author(s) -
Nishizuka Makoto,
Horinouchi Wataru,
Yamada Eri,
Ochiai Natsuki,
Osada Shigehiro,
Imagawa Masayoshi
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12465
Subject(s) - chemistry , phosphorylation , adipose tissue , microbiology and biotechnology , adipogenesis , endocrinology , bk channel , insulin , medicine , biology , biochemistry , membrane potential
KCNMA 1 is a pore‐forming α‐subunit of the large conductance Ca 2+ ‐ and voltage‐activated K + channels, referred to as BK channels, which play key roles in various physiological functions. However, the role of KCNMA 1 in mature adipocytes remains unclear. In this study, we reveal that kcnma1 expression is downregulated in white adipose tissue of mice fed a high‐fat diet and in hypertrophied adipocytes. Furthermore, inhibition of kcnma1 expression or treatment with a BK channel blocker attenuated insulin‐induced Akt phosphorylation in mature adipocytes. These results strongly indicate that KCNMA 1 contributes to the regulation of insulin signalling in mature adipocytes.