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Glycogen metabolism in the glucose‐sensing and supply‐driven β‐cell
Author(s) -
Andersson Lotta E.,
Nicholas Lisa M.,
Filipsson Karin,
Sun Jiangming,
Medina Anya,
AlMajdoub Mahmoud,
Fex Malin,
Mulder Hindrik,
Spégel Peter
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12460
Subject(s) - glycogenesis , glycogen , glycogen synthase , glycogenolysis , insulin , medicine , endocrinology , glycogen debranching enzyme , carbohydrate metabolism , glycogen branching enzyme , metabolism , biology , glycogen phosphorylase , chemistry
Glycogen metabolism in β‐cells may affect downstream metabolic pathways controlling insulin release. We examined glycogen metabolism in human islets and in the rodent‐derived INS‐1 832/13 β‐cells and found them to express the same isoforms of key enzymes required for glycogen metabolism. Our findings indicate that glycogenesis is insulin‐independent but influenced by extracellular glucose concentrations. Levels of glycogen synthase decrease with increasing glucose concentrations, paralleling accumulation of glycogen. We did not find cAMP‐elicited glycogenolysis and insulin secretion to be causally related. In conclusion, our results reveal regulated glycogen metabolism in human islets and insulin‐secreting cells. Whether glycogen metabolism affects insulin secretion under physiological conditions remains to be determined.