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miR‐296 inhibits proliferation and induces apoptosis by targeting FGFR 1 in human hepatocellular carcinoma
Author(s) -
Wang Liyan,
Bo Xiaotong,
Zheng Qinghua,
Xiao Xuhua,
Wu Linling,
Li Bin
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12442
Subject(s) - hepatocellular carcinoma , apoptosis , cancer research , biomarker , fibroblast growth factor receptor 1 , cell growth , cell cycle , fibroblast growth factor receptor , in vitro , biology , receptor , chemistry , medicine , fibroblast growth factor , biochemistry , genetics
MiR‐296 was previously reported to be underexpressed in hepatocellular carcinoma ( HCC ). However, the clinical value of miR‐296 and its function in HCC remain poorly understood. In this study, we found that miR‐296 levels are decreased in HCC specimens and cells, and that the underexpression of miR‐296 is associated with adverse clinical parameters and poor overall survival rate. In vitro experiments indicate that miR‐296 inhibits proliferation, colony formation, and cell cycle progression, and enhances apoptosis in HCC cells. Notably, we found that the fibroblast growth factor receptor 1 ( FGFR 1) is a downstream target that mediates the functions of miR‐296 in HCC . Thus, our findings indicate that miR‐296 exerts a tumor suppressive role in HCC and is a potential biomarker and drug‐target.