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Targeted disruption of the mouse protein phosphatase ppm1l gene leads to structural abnormalities in the brain
Author(s) -
Kusano Rie,
Fujita Kousuke,
Shinoda Yasuharu,
Nagaura Yuko,
Kiyonari Hiroshi,
Abe Takaya,
Watanabe Toshio,
Matsui Yasuhisa,
Fukaya Masahiro,
Sakagami Hiroyuki,
Sato Tatsuya,
Funahashi Junichi,
Ohnishi Motoko,
Tamura Shinri,
Kobayashi Takayasu
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12429
Subject(s) - forebrain , biology , phosphatase , microbiology and biotechnology , protein phosphatase 2 , ceramide , central nervous system , gene , neuroscience , genetics , phosphorylation , apoptosis
PPM 1L, a member of the metal‐dependent protein phosphatase ( PPM ) family, is involved in regulating the stress‐activated protein kinase pathway and ceramide trafficking. However, the physiological function of PPM 1L in the brain is unclear. In this study, we generated and analyzed ppm1l ‐deficient mice in order to investigate PPM 1L functions in the brain. Our results indicate that ppm1l is highly expressed in the central nervous system during mouse development and that ppm1l Δ/Δ mice display impaired motor performance and morphological abnormalities in the forebrain. Electron microscopic and immunohistochemical analyses suggest that these abnormalities are due to impaired axonal tract formation. Our novel findings suggest an important role for PPM 1L in brain development.