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Understanding the regulation of vertebrate hematopoiesis and blood disorders – big lessons from a small fish
Author(s) -
Robertson Anne L.,
Avagyan Serine,
Gansner John M.,
Zon Leonard I.
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12415
Subject(s) - zebrafish , haematopoiesis , biology , vertebrate , stem cell , blood cell , hematopoietic stem cell , fish <actinopterygii> , lineage (genetic) , neuroscience , immunology , microbiology and biotechnology , genetics , gene , fishery
Hematopoietic stem cells ( HSC s) give rise to all differentiated blood cells. Understanding the mechanisms that regulate self‐renewal and lineage specification of HSC s is key for developing treatments for many human diseases. Zebrafish have emerged as an excellent model for studying vertebrate hematopoiesis. This review will highlight the unique strengths of zebrafish and important findings that have emerged from studies of blood development and disorders using this system. We discuss recent advances in our understanding of hematopoiesis, including the origin of HSC s, molecular control of their development, and key signaling pathways involved in their regulation. We highlight significant findings from zebrafish models of blood disorders and discuss their application for investigating stem cell dysfunction in disease and for the development of new therapeutics.