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p110α and p110β isoforms of PI 3K signaling: are they two sides of the same coin?
Author(s) -
Singh Paramjeet,
Dar Mohd Saleem,
Dar Mohd Jamal
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12377
Subject(s) - gene isoform , p110α , microbiology and biotechnology , biology , signal transduction , subcellular localization , phosphatidylinositol , genetics , gene , cytoplasm
Class‐1 phosphatidylinositol‐3‐kinases ( PI 3Ks) are activated by a variety of extracellular stimuli and have been implicated in a wide range of cellular processes. p110α and p110β are the two most studied isoforms of the class‐1A PI 3K signaling pathway. Although these two isoforms are ubiquitously expressed and play multiple redundant roles, they also have distinct functions within the cell. More recently, p110α and p110β isoforms have been shown to translocate into the nucleus and play a role in DNA replication and repair, and in cell cycle progression. In the following Review article, we discuss the overlapping and unique roles of p110α and p110β isoforms with a particular focus on their structure, expression analysis, subcellular localization, and signaling contributions in various cell types and model organisms.