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Identification of functional farnesoid X receptors in brain neurons
Author(s) -
Huang Chao,
Wang Jili,
Hu Wenfeng,
Wang Chengniu,
Lu Xu,
Tong Lijuan,
Wu Feng,
Zhang Wei
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12373
Subject(s) - farnesoid x receptor , microbiology and biotechnology , cytoplasm , nuclear receptor , messenger rna , receptor , nucleus , biology , neuroscience , chemistry , transcription factor , biochemistry , gene
Farnesoid X receptor ( FXR ) has been confirmed to sense bile acids in various tissues. However, its expression in brain neurons remains obscure. In this study, we identified FXR mRNA and protein expression in mouse brain neurons and in mouse/human brain tissues. FXR was predominantly localized in the nucleus in cultured neurons, but in neurons in vivo , it mainly appeared in the cytoplasm. In nuclear compartments, the neuronal FXR exhibited a punctate distribution. Activation of FXR increased the small heterodimer partner ( SHP ) mRNA and protein expression levels in cultured neurons and in brain tissues. These findings will help explore new functions of FXR in the brain.