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Chromatin programming by developmentally regulated transcription factors: lessons from the study of haematopoietic stem cell specification and differentiation
Author(s) -
Obier Nadine,
Bonifer Constanze
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12343
Subject(s) - biology , chromatin , epigenetics , haematopoiesis , transcription factor , stem cell , cellular differentiation , regulation of gene expression , microbiology and biotechnology , gene expression , computational biology , context (archaeology) , gene , genetics , paleontology
Although the body plan of individuals is encoded in their genomes, each cell type expresses a different gene expression programme and therefore has access to only a subset of this information. Alterations to gene expression programmes are the underlying basis for the differentiation of multiple cell types and are driven by tissue‐specific transcription factors ( TF s) that interact with the epigenetic regulatory machinery to programme the chromatin landscape into transcriptionally active and inactive states. The haematopoietic system has long served as a paradigm for studying the molecular principles that regulate gene expression in development. In this review article, we summarize the current knowledge on the mechanism of action of TF s regulating haematopoietic stem cell specification and differentiation, and place this information into the context of general principles governing development.