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Revisiting the scissor‐like mechanism of activation for the erythropoietin receptor
Author(s) -
Corbett Michael S. P.,
Poger David,
Mark Alan E.
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12340
Subject(s) - receptor , erythropoietin , mechanism (biology) , cytokine , ligand (biochemistry) , chemistry , cytokine receptor , microbiology and biotechnology , socs2 , biophysics , computational biology , biology , immunology , endocrinology , biochemistry , physics , gene , quantum mechanics , suppressor
An interpretation of alternative crystal structures of the erythropoietin receptor, with and without ligand, led to the proposal of a scissor‐like mechanism of activation. This model has been propagated in the literature and is still being used to interpret crystal structures of related type‐I cytokine receptors. Here, we assess whether the model remains compatible with current knowledge on the family of type‐I cytokine receptors, and consider whether the model, as initially presented, is truly supported by the crystal structures on which it was originally based.