MiR‐329 suppresses osteosarcoma development by downregulating Rab10

MiR‐329 has been proved to be a tumor suppressor gene in various malignancies, however, its role in osteosarcoma remains elusive. We found that miR‐329 is remarkably downregulated in osteosarcoma tissues and relates to advanced stages. MiR‐329 is able to inhibit osteosarcoma cell proliferation, promote apoptosis, and induce G0/G1 cell cycle arrest. In addition, miR‐329 also suppresses wound‐healing and migration ability of osteosarcoma cells and inhibits tumorigenicity in vivo . Rab10 was identified as a target of miR‐329 in osteosarcoma and mediates its biofunction. These findings may shed light to the understanding of tumor development in osteosarcoma.