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The CREB ‐binding protein affects the circadian regulation of behaviour
Author(s) -
Maurer Christian,
Winter Tobias,
Chen Siwei,
Hung HsiuCheng,
Weber Frank
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12336
Subject(s) - circadian rhythm , circadian clock , creb , bacterial circadian rhythms , biology , transcription factor , light effects on circadian rhythm , microbiology and biotechnology , coactivator , creb binding protein , transcription (linguistics) , neuroscience , endocrinology , medicine , genetics , gene , linguistics , philosophy
Rhythmic changes in light and temperature conditions form the primary environmental cues that synchronize the molecular circadian clock of most species with the external cycles of day and night. Previous studies established a role for the CREB ‐binding protein ( CBP ) in molecular clock function by coactivation of circadian transcription. Here, we report that moderately increased levels of CBP strongly dampen circadian behavioural rhythms without affecting molecular oscillations of circadian transcription. Interestingly, light–dark cycles as well as high temperature facilitated a circadian control of behavioural activity. Based on these observations we propose that in addition to its coactivator function for circadian transcription, CBP is involved in the regulation of circadian behaviour down‐stream of the circadian clock.