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Programmed cell death acts at different stages of Drosophila neurodevelopment to shape the central nervous system
Author(s) -
PintoTeixeira Filipe,
Konstantinides Nikolaos,
Desplan Claude
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12298
Subject(s) - programmed cell death , biology , nervous system , mechanism (biology) , central nervous system , drosophila melanogaster , neuroscience , drosophila (subgenus) , cell fate determination , lineage (genetic) , neural development , neural cell , cell lineage , function (biology) , cell , microbiology and biotechnology , cellular differentiation , genetics , apoptosis , gene , transcription factor , philosophy , epistemology
Nervous system development is a process that integrates cell proliferation, differentiation, and programmed cell death ( PCD ). PCD is an evolutionary conserved mechanism and a fundamental developmental process by which the final cell number in a nervous system is established. In vertebrates and invertebrates, PCD can be determined intrinsically by cell lineage and age, as well as extrinsically by nutritional, metabolic, and hormonal states. Drosophila has been an instrumental model for understanding how this mechanism is regulated. We review the role of PCD in Drosophila central nervous system development from neural progenitors to neurons, its molecular mechanism and function, how it is regulated and implemented, and how it ultimately shapes the fly central nervous system from the embryo to the adult. Finally, we discuss ideas that emerged while integrating this information.