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Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development
Author(s) -
Omori Hisayoshi,
Ogaki Soichiro,
Sakano Daisuke,
Sato Mutsumi,
Umeda Kahoko,
Takeda Naoki,
Nakagata Naomi,
Kume Shoen
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12271
Subject(s) - pancreas , endocrine system , enteroendocrine cell , biology , embryonic stem cell , endocrinology , medicine , progenitor cell , cytoplasm , microbiology and biotechnology , embryogenesis , gene , embryo , stem cell , hormone , genetics
C2cd4c, encoded by a gene belonging to the C2cd4 family, contains a C2 domain conserved across species and is localized to the cytoplasm. To examine the role of C2cd4c in the pancreas, we studied its localization and generated C2cd4c knockout (KO) mice. C2cd4c was expressed in pancreatic endocrine progenitors at early embryonic stages. When endocrine cells arise from their precursors, C2cd4c is gradually confined to the insulin‐ and pancreatic polypeptide‐expressing cells of the endocrine. In the adult pancreas, C2cd4c is restricted to the beta cells. C2cd4c KO mice showed normal embryonic pancreatic development and adult pancreatic function. Thus, our results suggest that C2cd4c is dispensable for pancreatic development.