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Transcriptome activity of isochores during preimplantation process in human and mouse
Author(s) -
Barton Carl,
Iliopoulos Costas S.,
Pissis Solon P.,
Arhondakis Stilianos
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12245
Subject(s) - transcriptome , computational biology , embryonic stem cell , biology , rna seq , gene expression , microbiology and biotechnology , genetics , gene
This work investigates the role of isochores during preimplantation process. Using RNA‐seq data from human and mouse preimplantation stages, we created the spatio‐temporal transcriptional profiles of the isochores during preimplantation. We found that from early to late stages, GC‐rich isochores increase their expression while GC‐poor ones decrease it. Network analysis revealed that modules with few coexpressed isochores are GC‐poorer than medium‐large ones, characterized by an opposite expression as preimplantation advances, decreasing and increasing respectively. Our results reveal a functional contribution of the isochores, supporting the presence of structural‐functional interactions during maturation and early‐embryonic development.