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Micro RNA ‐146a represses LRP 2 translation and leads to cell apoptosis in Alzheimer's disease
Author(s) -
Zhang Bei,
Wang LiLing,
Ren RuJing,
Dammer Eric B.,
Zhang YongFang,
Huang Yue,
Chen ShengDi,
Wang Gang
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12229
Subject(s) - rna , downregulation and upregulation , rna binding protein , translation (biology) , messenger rna , protein kinase b , microbiology and biotechnology , apoptosis , chemistry , cell , receptor , antisense rna , cancer research , biology , gene , biochemistry
Micro RNA regulation of transcript expression has been reported in patients with Alzheimer's disease ( AD ). Here, we investigate the role of micro RNA ‐146a (mi RNA ‐146a), a brain‐enriched mi RNA , which is upregulated in AD patients. Through analysis of predicted targets of mi RNA ‐146a, low‐density lipoprotein receptor‐related protein‐2 (Lrp2), a member of the LDLR family that is known to play a protective role in AD , was identified. Overexpression of mi RNA ‐146a in SH ‐ SY 5Y cells significantly decreased Lrp2 expression, resulting in a reduction of Akt activation and induction of proapoptotic caspase‐3, thereby increasing cell apoptosis. Thus, specific mi RNA ‐146a regulation may contribute to AD by downregulating the Lrp2/Akt pathway.