Micro RNA ‐146a represses  LRP 2 translation and leads to cell apoptosis in Alzheimer's disease | Zendy

Zhang Bei | Zendy; Wang LiLing | Zendy; Ren RuJing | Zendy; Dammer Eric B. | Zendy; Zhang YongFang | Zendy; Huang Yue | Zendy; Chen ShengDi | Zendy; Wang Gang | Zendy

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Micro RNA ‐146a represses LRP 2 translation and leads to cell apoptosis in Alzheimer's disease

Author(s) -

Zhang Bei,

Wang LiLing,

Ren RuJing,

Dammer Eric B.,

Zhang YongFang,

Huang Yue,

Chen ShengDi,

Wang Gang

Publication year - 2016

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1002/1873-3468.12229

Subject(s) - rna , downregulation and upregulation , rna binding protein , translation (biology) , messenger rna , protein kinase b , microbiology and biotechnology , apoptosis , chemistry , cell , receptor , antisense rna , cancer research , biology , gene , biochemistry

Micro RNA regulation of transcript expression has been reported in patients with Alzheimer's disease ( AD ). Here, we investigate the role of micro RNA ‐146a (mi RNA ‐146a), a brain‐enriched mi RNA , which is upregulated in AD patients. Through analysis of predicted targets of mi RNA ‐146a, low‐density lipoprotein receptor‐related protein‐2 (Lrp2), a member of the LDLR family that is known to play a protective role in AD , was identified. Overexpression of mi RNA ‐146a in SH ‐ SY 5Y cells significantly decreased Lrp2 expression, resulting in a reduction of Akt activation and induction of proapoptotic caspase‐3, thereby increasing cell apoptosis. Thus, specific mi RNA ‐146a regulation may contribute to AD by downregulating the Lrp2/Akt pathway.

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