Transient receptor potential A1 channels regulate epithelial cell barriers formed by  MDCK  cells | Zendy

Dembla Sandeep | Zendy; Hasan Nouma | Zendy; Becker Alexander | Zendy; Beck Andreas | Zendy; Philipp Stephan Ernst | Zendy

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Transient receptor potential A1 channels regulate epithelial cell barriers formed by MDCK cells

Author(s) -

Dembla Sandeep,

Hasan Nouma,

Becker Alexander,

Beck Andreas,

Philipp Stephan Ernst

Publication year - 2016

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1002/1873-3468.12183

Subject(s) - transient receptor potential channel , microbiology and biotechnology , chemistry , stimulation , biophysics , receptor , cell culture , biology , biochemistry , neuroscience , genetics

Transient receptor potential A1 channels are well‐known as chemosensors in neuronal cells. However, recent studies also point to non‐neuronal functions in epithelia. Here, we show that TRPA 1 channels are expressed in epithelial MDCK II cells and contribute to Ca 2+ influx and whole‐cell currents after stimulation with AITC . Stimulation of TRPA 1 channels induced an immediate reduction of the transepithelial resistance of MDCK II cell layers that was blocked by the TRPA 1 antagonist HC ‐030031. The present data provide strong evidence for a new role of TRPA 1 channels in regulating the tightness of epithelial cell barriers.

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