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Enhancements of the production of bilirubin and the expression of β‐globin by carbon monoxide during erythroid differentiation
Author(s) -
Mu Anfeng,
Li Ming,
Tanaka Masakazu,
Adachi Yasushi,
Tai Tran Tien,
Liem Pham Hieu,
Izawa Shingo,
Furuyama Kazumichi,
Taketani Shigeru
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12178
Subject(s) - biliverdin , heme , bilirubin , erythropoiesis , carbon monoxide , globin , heme oxygenase , chemistry , hemoglobin , catabolism , biochemistry , biliverdin reductase , microbiology and biotechnology , biology , metabolism , anemia , medicine , endocrinology , enzyme , catalysis
Heme is degraded by heme oxygenase to form iron, carbon monoxide ( CO ), and biliverdin. However, information about the catabolism of heme in erythroid cells is limited. In this study, we showed the production and export of bilirubin in murine erythroleukemia ( MEL ) cells. The production of bilirubin by MEL cells was enhanced when heme synthesis was induced. When mouse bone marrow cells were induced with erythropoietin to differentiate into erythroid cells, the synthesis of bilirubin increased. The expression of β‐globin was enhanced by CO at the transcriptional level. These results indicate that constant production of CO from heme regulates erythropoiesis.