Lnc RNA H19 functions as a competing endogenous RNA to regulate AQP 3 expression by sponging miR‐874 in the intestinal barrier

Intestinal barrier dysfunction is a significant clinical problem, which develops in a variety of acute or chronic pathological conditions. In a previous study, we found that microRNA‐874 (miR‐874) suppresses aquaporin‐3 ( AQP 3) expression, which contributes significantly to intestinal barrier dysfunction. Recently, a new regulatory circuit was identified in which RNA can crosstalk with each other by competing for shared miRNA. Here, we show that the human long noncoding RNA (lnc RNA ) H19 may function as a competing endogenous RNA (ce RNA ) to regulate the expression of AQP 3 through competition for miR‐874, thus playing a significant role in maintaining intestinal barrier function.