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Lnc RNA H19 functions as a competing endogenous RNA to regulate AQP 3 expression by sponging miR‐874 in the intestinal barrier
Author(s) -
Su Zhaoran,
Zhi Xiaofei,
Zhang Qun,
Yang Li,
Xu Hao,
Xu Zekuan
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12171
Subject(s) - microrna , competing endogenous rna , rna , crosstalk , microbiology and biotechnology , endogeny , rna binding protein , long non coding rna , messenger rna , non coding rna , biology , gene , genetics , biochemistry , physics , optics
Intestinal barrier dysfunction is a significant clinical problem, which develops in a variety of acute or chronic pathological conditions. In a previous study, we found that microRNA‐874 (miR‐874) suppresses aquaporin‐3 ( AQP 3) expression, which contributes significantly to intestinal barrier dysfunction. Recently, a new regulatory circuit was identified in which RNA can crosstalk with each other by competing for shared miRNA. Here, we show that the human long noncoding RNA (lnc RNA ) H19 may function as a competing endogenous RNA (ce RNA ) to regulate the expression of AQP 3 through competition for miR‐874, thus playing a significant role in maintaining intestinal barrier function.