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In vivo models of hepatitis B and C virus infection
Author(s) -
Winer Benjamin Y.,
Ding Qiang,
Gaska Jenna M.,
Ploss Alexander
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12157
Subject(s) - virology , hepatitis d virus , biology , transmission (telecommunications) , hepatitis b virus , disease , virus , in vivo , liver disease , hepatitis c virus , hepatitis b , immunology , medicine , genetics , hbsag , pathology , biochemistry , electrical engineering , engineering
Globally, more than 500 million individuals are chronically infected with hepatitis B ( HBV ), delta ( HDV ), and/or C ( HCV ) viruses, which can result in severe liver disease. Mechanistic studies of viral persistence and pathogenesis have been hampered by the scarcity of animal models. The limited species and cellular host range of HBV , HDV , and HCV , which robustly infect only humans and chimpanzees, have posed challenges for creating such animal models. In this review, we will discuss the barriers to interspecies transmission and the progress that has been made in our understanding of the HBV , HDV , and HCV life cycles. Additionally, we will highlight a variety of approaches that overcome these barriers and thus facilitate in vivo studies of these hepatotropic viruses.