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Matrix Gla protein repression by miR‐155 promotes oncogenic signals in breast cancer MCF‐7 cells
Author(s) -
Tiago Daniel M.,
Conceição Natércia,
Caiado Helena,
Laizé Vincent,
Cancela Maria Leonor
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12155
Subject(s) - breast cancer , oncomir , cancer research , psychological repression , matrix gla protein , cancer cell , cancer , microrna , biology , calcification , microbiology and biotechnology , chemistry , medicine , suppressor , gene , gene expression , biochemistry , ectopic calcification
MGP is a protein that was initially associated with the inhibition of calcification in skeleton, soft tissues, and arteries, but more recently also implicated in cancer. In breast cancer, higher levels of MGP mRNA were associated with poor prognosis, but since this deregulation was never demonstrated at the protein level, we postulated the involvement of a post‐transcriptional regulatory mechanism. In this work we show that MGP is significantly repressed by miR‐155 in breast cancer MCF‐7 cells, and concomitantly there is a stimulation of cell proliferation and cell invasiveness. This study brings new insights into the putative involvement of MGP and oncomiR‐155 in breast cancer, and may contribute to develop new therapeutic strategies.