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miR‐152 induces human dental pulp stem cell senescence by inhibiting SIRT 7 expression
Author(s) -
Gu Shensheng,
Ran Shujun,
Liu Bin,
Liang Jingping
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12138
Subject(s) - senescence , downregulation and upregulation , microrna , dental pulp stem cells , microbiology and biotechnology , sirtuin 1 , phenotype , biology , stem cell , bioinformatics , cancer research , gene , biochemistry
Human dental pulp stem cells ( HDPSC s) have potential applications in regenerative medicine. The molecular mechanisms underlying HDPSC senescence are not completely understood. Here, we investigated the significance of miR‐152 in HDPSC senescence. We show that miR‐152 is upregulated during HDPSC senescence and its overexpression in early passaged HDPSC s induced senescence. Sirtuin 7 ( SIRT 7) was identified as a target of miR‐152. SIRT 7 was downregulated in senescent HDPSC s, whereas miR‐152 inhibition upregulated SIRT 7 and suppressed the senescent phenotype and SIRT 7 overexpression rescued miR‐152‐induced senescence. Our results demonstrate that the miR‐152/ SIRT 7 axis plays a key role in the regulation of HDPSC senescence and provide a candidate target to improve the functional and therapeutic potential of HDPSC s.