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Protein–lipid interactions critical to replication of the influenza A virus
Author(s) -
Chlanda Petr,
Zimmerberg Joshua
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12118
Subject(s) - viral matrix protein , membrane curvature , hemagglutinin (influenza) , viral membrane , biology , lipid bilayer fusion , viral replication , influenza a virus , membrane protein , microbiology and biotechnology , viral envelope , neuraminidase , vp40 , viral entry , orthomyxoviridae , genome , virus , virology , lipid bilayer , membrane , biochemistry , gene
Influenza A virus ( IAV ) assembles on the plasma membrane where viral proteins localize to form a bud encompassing the viral genome, which ultimately pinches off to give rise to newly formed infectious virions. Upon entry, the virus faces the opposite task—fusion with the endosomal membrane and disassembly to deliver the viral genome to the cytoplasm. There are at least four influenza proteins—hemagglutinin ( HA ), neuraminidase ( NA ), matrix 1 protein (M1), and the M2 ion channel—that are known to directly interact with the cellular membrane and modify membrane curvature in order to both assemble and disassemble membrane‐enveloped virions. Here, we summarize and discuss current knowledge of the interactions of lipids and membrane proteins involved in the IAV replication cycle.