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Beta3 adrenergic receptor is involved in vascular injury in deoxycorticosterone acetate‐salt hypertensive mice
Author(s) -
Sheng LiJuan,
Ruan ChengChao,
Ma Yu,
Chen DongRui,
Kong LingRan,
Zhu DingLiang,
Gao PingJin
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12107
Subject(s) - endocrinology , medicine , downregulation and upregulation , adipose tissue , lipolysis , receptor , desoxycorticosterone acetate , chemistry , antagonist , thermogenin , brown adipose tissue , adrenergic receptor , white adipose tissue , adrenergic , vasodilation , biochemistry , gene
Beta3 adrenergic receptor ( ADRB 3) mediates vessel relaxation in the endothelium while it modulates lipolysis in the adipose tissue. However, the function and regulation mechanism of ADRB 3 in the perivascular adipose tissue ( PVAT ), especially in hypertension, is still unclear. We show that ADRB 3 protein is upregulated in the PVAT of deoxycorticosterone acetate‐salt ( DOCA ‐salt) hypertensive mice, with the characteristics of PVAT browning and increased uncoupling protein 1 ( UCP 1) expression. Inhibition of ADRB 3 with selective antagonist SR 59230A caused serious vascular injury in vivo , even though UCP 1 expression was downregulated. ADRB 3 protein was regulated by let‐7b, which was decreased in the PVAT of the DOCA ‐salt group. These data reveal that ADRB 3 in PVAT contributes to vascular function in the progression of hypertension.