Premium
Long noncoding RNA H19 inhibits the proliferation of fetal liver cells and the Wnt signaling pathway
Author(s) -
Wang Shaobing,
Wu Xia,
Liu Yan,
Yuan Jihang,
Yang Fu,
Huang Jinfeng,
Meng Qingyang,
Zhou Chuanchuan,
Liu Feng,
Ma Jinzhao,
Sun Shuhan,
Zheng Jiasheng,
Wang Fang
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12078
Subject(s) - wnt signaling pathway , heterogeneous nuclear ribonucleoprotein , ribonucleoprotein , microbiology and biotechnology , long non coding rna , heterogeneous ribonucleoprotein particle , lrp5 , biology , psychological repression , signal transduction , gene , cell growth , lrp6 , rna , gene expression , genetics
In this study, we found that H19 is the most strongly differentially expressed long noncoding RNA (lncRNA) during liver development. H19 may inhibit the proliferation of fetal liver cells by blocking the interaction between heterogeneous nuclear ribonucleoprotein (hnRNP) U and actin, which results in gene transcriptional repression. Based on ChIP‐seq analysis, we found that genes involved in the Wnt signaling pathway are enriched among hnRNP U‐binding genes. Further investigation demonstrated that hnRNP U has opposing effects on cell proliferation and Wnt/β‐catenin signaling pathway activity compared to H19 and that hnRNP U is very important in this process.