Open AccessOptimized Production of Sodium Cellulose Sulfate (NaCS) for Microencapsulation of Cell Cultures
Author(s) -
Bohlmann J.T.,
Schneider C.,
Andresen H.,
Buchholz R.
Publication year - 2002
Publication title -
engineering in life sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.547
H-Index - 57
eISSN - 1618-2863
pISSN - 1618-0240
DOI - 10.1002/1618-2863(20021210)2:12<384::aid-elsc384>3.0.co;2-l
Subject(s) - cellulose , reagent , sulfuric acid , chemistry , membrane , sulfate , sodium , hydrolysis , sodium sulfate , hydroxypropyl cellulose , chemical engineering , chromatography , biochemistry , organic chemistry , polymer , engineering
Membrane capsules built of sodium cellulose sulfate (NaCS) and PDADMAC offer major advantages over conventional membrane systems and have already been applied successfully in antibody production as well as in tumor therapy. The production of sodium cellulose sulfate by heterogeneous sulfating of cellulose is performed in a liquid reagent composed of sulfuric acid and isopropanol. The performance of each of the process steps and their effects on the final product quality have not been fully investigated yet.