Open AccessBioprocess Development for the Cultivation of Human T‐lymphocytes
Author(s) -
Hilbert U.,
Jelinek N.,
Schmidt S.,
Biselli M.
Publication year - 2001
Publication title -
engineering in life sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.547
H-Index - 57
eISSN - 1618-2863
pISSN - 1618-0240
DOI - 10.1002/1618-2863(200107)1:1<20::aid-elsc20>3.0.co;2-t
Subject(s) - bioprocess , development (topology) , bioprocess engineering , biochemical engineering , computational biology , biology , microbiology and biotechnology , computer science , engineering , mathematics , mathematical analysis , paleontology
The ex vivo expansion of human T‐lymphocytes is of increasing importance in medical applications, especially for the adoptive immunotherapy of viral infection and malignant diseases of immunosuppressed patients. In these therapies, the cells of the patient are isolated from the blood and subsequently cultivated, expanded, and / or genetically modified ex vivo . Afterwards, these expanded or modified cells are transplanted back into the patient.