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Rapid induction of thermoreversible hydrogel formation based on poly(propylene glycol)‐grafted dextran inclusion complexes
Author(s) -
Choi Hak Soo,
Kontani Kazuo,
Huh Kang Moo,
Sasaki Shintaro,
Ooya Tooru,
Lee Won Kyu,
Yui Nobuhiko
Publication year - 2002
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/1616-5195(200208)2:6<298::aid-mabi298>3.0.co;2-#
Subject(s) - dextran , polymer chemistry , chemistry , polyvinyl alcohol , self healing hydrogels , inclusion (mineral) , chemical engineering , polymer science , organic chemistry , mineralogy , engineering
Poly(propylene glycol) (PPG)‐grafted dextran was synthesized by conjugating amino‐terminated PPG with hydroxyl groups of dextran, and its inclusion complexation property was investigated. The average number of grafted PPG per dextran was changeable in the range of 1.1 to 38.5. The formation of inclusion complexes between the PPG grafts and β ‐cyclodextrins ( β ‐CDs) and their crystalline structures were characterized by 13 C CP/MAS NMR and X‐ray spectroscopies. These hydrogel systems showed a thermally reversible sol–gel transition based on supramolecular assembly and dissociation between host and guest moieties. The results of rheological measurements and sol–gel transition temperature of the hydrogels suggested that the aggregated channel‐type crystalline domain was critical to control the transition temperature in terms of initial feed molar ratio of PPG and β ‐CD and the graft number of PPG constituents. These thermoreversible hydrogel systems showed rapid gelation properties, which may be useful for biomedical application, especially injectable drug delivery systems.Sol–gel phase transition of ICs between PPG‐grafted dextrans and β ‐CDs. (conc. of IC was fixed at 20 wt.‐%).