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NMR structural study of hydrogels based on partially deacetylated hyaluronan
Author(s) -
Crescenzi Vittorio,
Francescangeli Andrea,
Segre Anna Laura,
Capitani Donatella,
Mannina Luisa,
Renier Davide,
Bellini Davide
Publication year - 2002
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/1616-5195(200208)2:6<272::aid-mabi272>3.0.co;2-v
Subject(s) - self healing hydrogels , glutaraldehyde , polymer chemistry , aqueous solution , chemistry , aqueous medium , chemical engineering , organic chemistry , engineering
Hydrogels have been prepared using two partially deacetylated hyaluronan (deHA) samples having a molar ratio of free amino groups to total initial N ‐acetamido groups equal to 23 and 33%, respectively. Taking advantage of such primary amino functionalities, polymeric networks could be easily obtained in aqueous media by means of two different crosslinking procedures, namely: a) Ugi multicomponent reactions and, more simply, b) glutaraldehyde reticulation. In this paper, we wish to report on the synthesis of deHA based hydrogels and, in particular, on their structural elucidation as obtained by NMR studies.Structure of HA (R = COCH 3 ) and de‐HA (R = H) repeat units.