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Side‐Product of N ‐Acryloyloxysuccinimide Synthesis or Useful New Bifunctional Monomer?
Author(s) -
D'Agosto Franck,
Charreyre MarieThérèse,
Pichot Christian
Publication year - 2001
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/1616-5195(20011001)1:7<322::aid-mabi322>3.0.co;2-f
Subject(s) - bifunctional , monomer , chemistry , derivative (finance) , acrylamide , polymer chemistry , polymer , solubility , covalent bond , biomolecule , molecule , combinatorial chemistry , organic chemistry , biochemistry , financial economics , economics , catalysis
During the synthesis of the N ‐acryloxysuccinimide (NAS) monomer, we observed the formation of a by‐product, resulting from the condensation of two NAS molecules via a Michael addition. Due to its bulky structure, this new bifunctional monomer shows a very poor ability to homopolymerize. On the contrary, it readily copolymerizes with N ‐acryloylmorpholine (NAM), an hydrophilic acrylamide derivative, leading to functional polymer chains exhibiting a wide range of solubility and a high potential for biomolecule covalent binding.