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Synthesis of Biodegradable Amphoteric Poly[(aspartic acid) ‐co‐ lysine] by Thermal Polycondensation
Author(s) -
Jiang H. L.,
Tang G. P.,
Zhu K. J.
Publication year - 2001
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/1616-5195(20010801)1:6<266::aid-mabi266>3.0.co;2-k
Subject(s) - succinimide , lysine , chemistry , condensation polymer , cationic polymerization , polymer chemistry , aspartic acid , polymerization , organic chemistry , hydrolysis , amine gas treating , polymer , amino acid , biochemistry
A new class of biodegradable polyampholytes, poly[(aspartic acid) ‐co‐ lysine], were synthesized by thermal polycondensation of aspartic acid and lysine under reduced pressure and subsequent hydrolysis. Polymerization conditions were optimized to yield maximal water‐soluble poly(succinimide ‐co‐ lysine) with high molecular weight (160°C/3.5 h). The succinimide/lysine ratio in the polyampholytes could be adjusted by their feed ratio. Characterization of the poly(succinimide ‐co‐ lysine) by 1 H NMR revealed that ω ‐amine and carboxylic groups in lysine participated in the polymerization, leaving α ‐amino groups as pendant cationic moieties.