Premium
Towards the molecular dissection of fertilization signaling: Our functional genomic/proteomic strategies
Author(s) -
Sato Kenichi,
Iwasaki Tetsushi,
Sakakibara Kenichi,
Itakura Shuji,
Fukami Yasuo
Publication year - 2002
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/1615-9861(200209)2:9<1079::aid-prot1079>3.0.co;2-p
Subject(s) - computational biology , proteomics , biology , genetics , gene
Abstract Recent advances in DNA sequencing techniques and automated informatics has led to clarification of all genome sequence of some model organisms in a very short period. The demonstration of the first draft sequence of the human genome has prompted us to elaborate new approaches in biology, pharmacology and medicine. Such new research will focus on high throughput methods to function on collections of genes, and hopefully, on a genome‐wide, quantitative modeling of the cell system as a whole. In this review article, we discuss the present status of “post genome sequencing” approaches in line with our strategies for understanding the molecular mechanism of fertilization and activation of development using the African clawed frog, Xenopus laevis , as a model system.