Premium
Contribution of proteomics to the molecular analysis of renal cell carcinoma with an emphasis on manganese superoxide dismutase
Author(s) -
Sarto Cecilia,
Déon Catherine,
Doro Giancarlo,
Hochstrasser Denis F.,
Mocarelli Paolo,
Sanchez JeanCharles
Publication year - 2001
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/1615-9861(200110)1:10<1288::aid-prot1288>3.0.co;2-#
Subject(s) - proteomics , renal cell carcinoma , superoxide dismutase , manganese , carcinoma , chemistry , cancer research , medicine , biochemistry , pathology , oxidative stress , gene , organic chemistry
Renal cell carcinoma (RCC) originates in the renal cortex. It accounts for 2–3 percent of all cancers occuring in adults and it is characterised by lack of early clinical manifestations, unpredictable outcome, and absence of effective treatment modalities except early surgery. RCC comprises a heterogeneous group of tumours with various molecular and cytogenetic abnormalities and different histological features as cell types and tumour architecture. Molecular genetic and proteomic tools led to the discovery of potential diagnostic prognostic and therapeutic biomarkers of RCC. In this review we discuss recent developments in understanding genotype‐phenotype relationships, with attention to manganese superoxide dismutase, a mitochondrial enzyme related to the redox cycle which affects various regulatory functions of cells. The expression of this protein has been evaluated in numerous human tumour types including RCC, and post‐translational modifications are being investigated.