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Back to the future: The human protein index (HPI) and the agenda for post‐proteomic biology
Author(s) -
Anderson Norman G.,
Matheson Alastair,
Anderson N. Leigh
Publication year - 2001
Publication title -
proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.26
H-Index - 167
eISSN - 1615-9861
pISSN - 1615-9853
DOI - 10.1002/1615-9861(200101)1:1<3::aid-prot3>3.0.co;2-t
Subject(s) - human genome , genome , computational biology , index (typography) , dna sequencing , biology , genome project , data science , proteomics , genetics , computer science , dna , gene , world wide web
Abstract The effort to produce an index of all human proteins (the human protein index, or HPI) began twenty years ago, before the initiation of the human genome program. Because DNA sequencing technology is inherently simpler and more scalable than protein analytical technology, and because the finiteness of genomes invited a spirit of rapid conquest, the notion of genome sequencing has displaced that of protein databases in the minds of most molecular biologists for the last decade. However, now that the human genome sequence is nearing completion, a major realignment is under way that brings proteins back to the center of biological thinking. Using an influx of new and improved protein technologies – from mass spectrometry to re‐engineered two‐dimensional (2‐D) gel systems, the original objectives of the HPI have been expanded and the time frame for its execution radically shortened. Several additional large scale technology efforts flowing from the HPI are also described.