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Enantioseparations of dansyl amino acids by capillary electrophoresis using Cu(II) complexes with L‐amino acylamides as chiral selectors in electrolytes
Author(s) -
Chen Zilin,
Niitsuma Megumi,
Nakagama Tatsuro,
Uchiyama Katsumi,
Hobo Toshiyuki
Publication year - 2002
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/1615-9314(20021101)25:15/17<1197::aid-jssc1197>3.0.co;2-2
Subject(s) - enantiomer , capillary electrophoresis , chemistry , amino acid , electrolyte , chromatography , electrophoresis , combinatorial chemistry , organic chemistry , biochemistry , electrode
Enantioseparations of dansyl amino acids using Cu(II) complexes with L‐Amino acylamides as the chiral selectors in the electrolyte solution were investigated by capillary electrophoresis. It has been demonstrated that the Cu(II) complexes with L‐amino acylamides such as L‐phenylalaninamide, L‐prolinamide, and L‐alaninamide are suitable for use as chiral selectors for enantioseparations of dansyl amino acids. The optimal separation conditions were examined. The employed chiral ligands exhibited different enantioselectivities and enantiomer migration orders. The enantiomer migration orders are discussed by using three different chiral selectors. L‐enantiomers migrate faster than D‐enantiomers when Cu(II)‐L‐phenylalaninamide and Cu(II)‐L‐alaninamide are used as chiral selectors, but D‐enantiomers faster than their L‐counterparts in the Cu(II)‐L‐prolinamide system.