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Melting gel techniques in single nucleotide polymorphism and mutation detection: From theory to automation
Author(s) -
Bjørheim Jens,
Gaudernack Gustav,
Ekstrøm Per Olaf
Publication year - 2002
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/1615-9314(20020701)25:10/11<637::aid-jssc637>3.0.co;2-l
Subject(s) - single nucleotide polymorphism , polymorphism (computer science) , nucleotide , computational biology , high resolution melt , chemistry , chromatography , biology , genetics , microbiology and biotechnology , materials science , gene , polymerase chain reaction , genotype
During the last 20 years several applications and variations of the melting gel techniques have been used for mutation and single nucleotide polymorphism analysis. All melting gel techniques are based on the same theoretical platform and are used by large groups in the research community. This review reports on current methods and applications in the field of melting gel techniques.