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Supported liquid membrane extraction of urinary trans, trans ‐muconic acid, a biomarker for benzene exposure
Author(s) -
Norberg Jan,
Tiruye Degu,
Mathiasson Lennart,
Jönsson Jan Åke
Publication year - 2002
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/1615-9314(20020401)25:5/6<351::aid-jssc351>3.0.co;2-h
Subject(s) - muconic acid , chromatography , chemistry , extraction (chemistry) , benzene , sample preparation , analyte , detection limit , metabolite , analytical chemistry (journal) , organic chemistry , biochemistry
In this study, sample preparation of urinary trans, trans ‐muconic acid (tt‐MA), a minor metabolite and biomarker of benzene, by means of Supported Liquid Membrane (SLM) extraction has been investigated. The sample extract was automatically transferred on‐line to an ion exchange chromatographic column and the analytes were detected using a photodiode array detector. Automation of the system was accomplished using a robotic sample preparation processor integrated into the chromatographic system. Detection limits calculated from the baseline noise was in the sub‐ppb range, and quantification of tt‐MA is safe down to 10 ppb.